Beclin1 Overexpression Inhibitis Proliferation, Invasion and Migration of CaSki Cells

Autophagy is one of the main types of programmed cell death different from apoptosis, and it is a catabolic process involving the degradation of cell’s own components (damaged macromolecules and organelles) through lysosomal machinery. The main role of this process is to maintain the balance between the synthesis, degradation, and subsequent recycling of cellular products. As great attention has been paid to apoptosis last century, autophagy has been a hot issue in recent research. The functional relationship between apoptosis and autophagy is complex in the sense that, in several scenarios, autophagy constitutes a stress adaptation that avoids cell death, whereas in other cellular settings, autophagy constitutes an alternative pathway to cellular demise that is called autophagic cell death (Maiuri et al., 2007). Nowadays, increasing studies have demonstrated the changes in autophagy and/or cell death due to autophagy are closely associated with the occurrence and development of malignancies. Studies also report autophagy may be a promising target for anti-cancer therapy in the future. The present study aimed to investigate the effect of autophagyrelated gene Beclin 1 on the proliferation, invasion and migration of cervical cancer CaSki cells. Our results may provide novel therapeutic target in the treatment of cervical cancer.